Which 2019 Probiotic Supplements Are The Most Effective?

By Dr. Kotb And his Team

We’ll show you what to look for and reveal the 3 biggest mistakes shoppers make when choosing a probiotic

Probiotics have been all over the news lately, especially now that both researchers and celebrity doctors alike are confirming the major connections our microbiome has to our overall health.

Despite its newfound popularity, many of us are still unclear about what exactly our microbiome is, why we need probiotics to help us keep it balanced, or which supplements are best to take.

With that in mind, we’ve compiled years of research about the microbiome and its effect on our health. This quick guide will help you discover everything you need to know to make the most informed decision about your probiotic supplement needs.

Why Is Our Microbiome Important, Anyway?

Right now, 90% of the cells in your body are microbial. These microbes –– a general term for bacteria, archaea, protists, and other molecular organisms –– are present throughout the body.

The human microbiome is the collection of all of these microbes. This means –– you guessed it –– 90% of your body is actually your microbiome. Keeping it balanced can have huge benefits not only for your digestion, but your brain, skin, immune system, and a host of other functions.

In fact, researchers are only scratching the surface of the potential of probiotic supplements, and why they’re essential for our overall wellbeing.

Unfortunately, many of us don’t realize that, even though our digestion feels normal, we may still need a quality probiotic supplement to keep us healthy.

Our modern western society has adopted unhealthy activities and lifestyles that affect our microbes in a variety of ways. Most are difficult –– if not impossible –– to avoid, but it’s critical to spread awareness if we want to protect our microbiome.


If any of these apply to you, it may be time to look for a high quality probiotic. Unfortunately, sometimes it’s difficult to know where to start, and many of our Smarter Shoppers reported regretting their first probiotic purchase. With this in mind, we included a section to help you skip their mistakes:

What Not To Do When Buying A Probiotic

Forget the Research

Many shoppers believe that it doesn’t matter which probiotic they choose. This is not the case. Many supplements contain ineffective and potentially harmful additives, such as artificial fillers and colors. Binders, including magnesium stearate, chromium, gelatin, and silicon dioxide, are other infamous additives to avoid.

Rely on Amazon Reviews

Millions of Americans look to Amazon reviews before purchasing their products, but most don’t realize that up to 60% have been paid for. Some disreputable, fly-by-night companies compensate individuals for positive reviews, regardless of whether they’ve tried the product or not. Risking your health with reviews that are likely false is too dangerous a game to play when you’re choosing an ingestible supplement.

Prioritize Price Over Quality

We found that many lower-priced and generic probiotic supplements only contain one strain, and even worse, don’t list substrains. Many of these companies also offer confusing guarantees that seem like a good deal at the time, but ultimately only hurt your wallet. Try to find a probiotic with the qualities listed below, even if that means they cost a little more than your local grocery store’s generic brand.

What You Should Look For In A Good Probiotic

Based on our research and feedback from our Smarter Shoppers, these are the things to look for in an exceptional probiotic supplement:

Formulated By A Doctor

It takes specific expertise to form an effective probiotic formulation. More is not necessarily better. The exact combination of strain type, quantity and prebiotics determines the product’s quality. Look for real doctors specializing in gut health backing the product.

High CFU Count

Since our microbiome is composed of about 100-trillion good and bad bacteria, a high number of CFUs will have greater impact on the growth of beneficial bacteria within your gut flora. Look for a formula with a minimum of 40 billion CFUs

Multiple Strains

Taking a probiotic with a variety of good bacteria strains can help balance your microbiome. Unfortunately, most probiotic supplements only provide one type of strain.  That’s why it’s crucial to find probiotics that use a comprehensive approach to promoting balance in your gut bacteria.

100% Vegan

Choosing an all-vegan supplement means that you avoid harmful gelatin capsules loaded with animal-based fillers like magnesium stearate fatty acids and carmine food dyes.

Try to find a supplement with at least 9 individual strains.

Focusing on the qualities above is a good start, but to find the best probiotics on the market, we suggest adding these little-known secrets to your research regimen.

The 3 Secrets of A High Quality Probiotic

It Lists Its Substrains

The substrains listed next to each strain indicates that a specific probiotic strain has undergone clinical studies. Many probiotic formulations do not list their specific substrains. This is a huge red flag that suggests they may be using generic (and cheaper) substrains that have not been clinically studied.

It Contains Prebiotics

The latest research shows using fiber-based prebiotics (such as NutraFlora Fiber) will help the probiotics populate and flourish in your gut. This will significantly increase the overall effectiveness of the probiotic.

It Doesn’t Require Refrigeration

Refrigerated products can be damaged during shipping. Another note: you’re not always going to have access to a refrigerator, so we suggest choosing a probiotic that is well-formulated to withstand room temperature and does not require being refrigerated during periods of non-use.

Our Specialized Ranking System

At Smarter Reviews, we employ a comprehensive evaluation system to analyze and measure the full value of products, by looking at the ingredients, clinical studies, safety, projected effectiveness, return policies, and overall customer satisfaction. This method is known as the Smarter Reviews Ranking System.



Top 10 Best Probiotics Reviewed in 2019


Top 10 Best Probiotics Reviewed in 2019

dr kotb and his team



Best Probiotics
Probiotics provide balanced, live organisms spectrum consisting of probiotic strains that are resistant. It is very important to have in our bodies, and they can be retrieved through the consumption of fermented greens, yogurt, pickles, and other food.

Many times, however, we don’t eat enough of those foods to maintain a good level of probiotics (good bacteria), and the result could be very ugly and uncomfortable. As a matter of fact, not consuming enough good bacteria can be quite dangerous to some people.

Just like vitamin supplements are required when people don’t get enough of them through foods, probiotics are needed also. And as we age, undergo a lot of stress, take antibiotics sometimes, and go through other situations, probiotics are significantly reduced in our bodies.

Having established the importance of probiotics, it’s always good to consult your healthcare provider first for recommendations. Also, it’s vital to know which probiotics are safer and more effective.

And having said that, the following are the top 10 best probiotics on the market in 2019.


  • 10. NatureWise Maximum Care Time-Release Probiotics
  • 9. Renew Life – Ultimate Flora Probiotic Extra Care
  • 8. Vitamin Bounty – Pro 50 Probiotic
  • 7. Dr. Tobias DEEP Immune Probiotics
  • 6. Nature’s Bounty Ultra Probiotic 10
  • 5. NOW Probiotic-10 25 Billion
  • 4. Nature’s Bounty Probiotic Acidophilus
  • 3. BioSchwartz Probiotic 40 Billion CFU
  • 2. Hyperbiotics PRO-15 Probiotics
  • 1. Nutrition Essentials #1 Rated Probiotic
  • Which Probiotic Supplement Should You Buy?

10. NatureWise Maximum Care Time-Release Probiotics

NatureWise Maximum Care Time-Release Probiotics

NatureWise Maximum Care Time-Release Probiotics is for women and men. This is a highly potent probiotic product that includes 40 caplets.

It also has twice the amount of strains; thus, it’s proven clinically to be more supportive of the immune response, overall health, and digestion than many other brands. As a matter of fact, the NatureWise Maximum Care Probiotics gives a timely released, live stream of active cultures that goes throughout the day through the GI tract.

Other wonderful qualities of this product include it being a vegetarian product, gluten-free, and a non-GMO product that is guaranteed to last in strength until their long-extended expiration date.


  • Has bonus beneficial ingredients, such as fermented greens
  • Has some of the largest amount of strains than others in the market
  • GMP certified


  • Requires two capsules daily
  • No prebiotics

Click here to buy from Amazon

9. Renew Life – Ultimate Flora Probiotic Extra Care

Renew Life - Ultimate Flora Probiotic Extra Care

The Ultimate Flora Probiotic supplement is filled with 50 billion cultures that are supportive of the immune and digestive health. These probiotics are for adults. The Ultimate Flora Probiotic supplement has 10 probiotic strains that are also beneficial for one’s digestive and immune health.

When taking daily, you will maintain a balance in your digestive system and obtain relief from occasional digestive discomfort. You will have more energy and feel better and lighter.

The Ultimate Flora Probiotic supplement also does not contain wheat, soy, salt, gluten, artificial ingredients, dairy, corn, binders, or yeast. Furthermore, potency, purity, and quality are guaranteed through expiration.


  • No side effects
  • Effective
  • Can eat things one normally can’t eat


  • It’s ineffective to some
  • Some say it wasn’t as much pills as displayed

Click here to buy from Amazon

8. Vitamin Bounty – Pro 50 Probiotic

Vitamin Bounty - Pro 50 Probiotic

With Vitamin Bounty Pro 50 Probiotic, you will get highly potent cultures for each serving, thus making this product one of the most effective probiotics available.

It supersedes many others in the market due to it having 13 probiotic strains, whereas many others have only one or two strains. With their excessive number of probiotic strains, this product ensures you will obtain the required support for overall digestive health.

The Vitamin Bounty Pro 50 Probiotic also utilizes a delayed-release and patented capsule which protects the cultures in the capsule from stomach acid. This, in turn, will deliver additional cultures and ensure maximum efficacy. Purity and potency are guaranteed. This product is also vegetarian capsules.


  • Guaranteed potency and purity
  • Contains fermented greens
  • Vegetarian capsules


  • Can cause lactose intolerance for some
  • While traveling, some complain of having an upset stomach

Click here to buy from Amazon

7. Dr. Tobias DEEP Immune Probiotics

Dr. Tobias DEEP Immune Probiotics

Dr. Tobias DEEP Immune Probiotics supplements have tons of wonderful benefits. They become effective within customers within hours. These supplements are spectacular for children, men, and women.

It contains four strains that are reinforced by their probiotic booster formula that only feeds good bacteria. Also, this product contains 4.4 billion CFU.

Another wonderful aspect of this product is that it’s proven to be protective against stomach acid. Unlike many others, it deeply delivers into one’s intestines.

They are vegetarian capsules, they have no after-taste, they have a long shelf-life, and no refrigeration is needed. It also consists of a month supply of 60 capsules which are delayed-released.


  • Produced in a GMP certified facility to ensure quality
  • Can help with weight loss
  • Works as advertised


  • May not be good if sensitive to allergens
  • Some didn’t see a difference

Click here to buy from Amazon

6. Nature’s Bounty Ultra Probiotic 10

Nature's Bounty Ultra Probiotic 10

Nature’s Bounty Ultra Probiotic supplements are loaded with tons of benefits as well. With a box containing 60 capsules, their probiotic formula is clinically studied.

Their Nature’s Bounty brands use several quality tastes throughout the manufacturing process to ensure potency and purity. They test the ingredients and final product through their microbiological lab by manufacturing specialists, scientists, and quality experts.

Nature’s Bounty Ultra Probiotic supplements meet the quality standards of GMP supplements. Another wonderful aspect of Nature’s Bounty Ultra Probiotic supplements includes them having 10 probiotic stains that assist in promoting nutrients’ absorption and aids in digestion.


  • Meet the standards of GMP supplement quality
  • Affordable
  • Effective


  • Made no to little difference to some
  • Leaves various uncomfortable side effects for some

Click here to buy from Amazon

5. NOW Probiotic-10 25 Billion

NOW Probiotic-10 25 Billion

NOW Probiotic-10 supplements support the health of one’s immune system. It contains 10 Probiotic strains which are clinically validated by DNA-fingerprinting technology, and it has 25 billion CFU potency.

It’s one of the best probiotic supplements in the industry due to its product integrity, quality, support, and price points. It also has no GMO. With these supplements, the human GI tract is naturally colonized. It comes in 30, 50, and 100 vegetarian capsules.


  • Perfectly regulates and balances the GI system
  • Maintain potency due to lightly resistant bottles
  • Free from dairy, gluten, and soy


  • Ineffective for some
  • Packaging issues

Click here to buy from Amazon

4. Nature’s Bounty Probiotic Acidophilus

Nature's Bounty Probiotic Acidophilus

Another one of the best probiotic supplements on the market, Nature’s Bounty Probiotic Acidophilus contains 240 Tablets, i.e. 2 x 120 count in each bottle. With only one capsule per day, you will get millions of live organisms which assist in obtaining a healthy immune function.

For adult use only, this supplement also encourages a healthy intestinal system. It relieves gas, bloating, and constipation. Other wonderful aspects of this product include the following: It assists in nutrient absorption, it guarantees quality, and it has no artificial flavor, color, sweetener, lactose, milk, sugar, starch, preservatives, sodium, fish, yeast, wheat, gluten, or soy.


  • Good value
  • Effective
  • Long lasting


  • Needs refrigeration after opening
  • A lot of air in bottle when first opened

Click here to buy from Amazon

3. BioSchwartz Probiotic 40 Billion CFU

BioSchwartz Probiotic 40 Billion CFU

Being for women and men, the BioSchwartz Probiotic contains 40 Billion CFU. Potency is guaranteed until the expiration date. It’s 20 times more effective than other probiotic supplements.

You will obtain stomach acid protection with this product to ensure strains will survive stomach acids and remain alive when it gets deep into the small intestines. BioSchwartz Probiotic also goes into the large intestines, thus making it 20 times more effective than other probiotic products.

Other wonderful aspects of this product include it being gluten-free, manufactured in a GMA and FDA facility in the US, and the boosting of digestive and immune health. Some have even lost weight due to accelerated fat loss and improved metabolism.


  • No refrigeration needed
  • Potency guaranteed until expiration date
  • Allergen and gluten free


  • May cause some digestive issues
  • Takes longer to be effective

Click here to buy from Amazon

2. Hyperbiotics PRO-15 Probiotics

Hyperbiotics PRO-15 Probiotics

With Hyperbiotics PRO-15 Probiotics, you will get 60 capsules which are 15 times more effective than other probiotics. This product’s live organisms will reach deeply into the intestinal tract where most needed.

The large intestines will also reach the large intestines. Also, with most of the immune system being in the gut, Hyperbiotics PRO-15 Probiotics will help ensure a healthy immune system.

It will replenish good bacteria for optimal immune and digestive health, assists in balancing yeast growth, and promote relief from irregularity, bloating, and gas on a daily basis.

You will also have a lift in your energy and mood due to it promoting full mineral absorption which will make you feel vibrant, energetic, and happy.


  • Effective
  • Easy to swallow
  • Completely natural


  • Must be store in a cool place once opened
  • Capsule too small for some

Click here to buy from Amazon

1. Nutrition Essentials #1 Rated Probiotic

Nutrition Essentials #1 Rated Probiotic

Nutrition Essentials is considered to be the number one probiotic to many for a plethora of reasons. For one, it has the highest amount of CFUs for each serving.

Secondly, you will get twice as much as other, similar probiotic supplements. It comes with a 60-day supply. Also, it ensures better bowel regularity and better immune and digestive health, or you can get a 100% money back, no questions asked guarantee.

Other amazing aspects of Nutrition Essentials include the following: It’s 100% natural, no refrigeration is needed, and it’s made with no preservatives, blenders, or fillers.


  • Very effective due to having the highest amount of CFUs
  • All natural
  • No refrigeration needed


  • Some digestive issue may occur
  • Only contain one strain (one type of fiber)

Click here to buy from Amazon

Which Probiotic Supplement Should You Buy?

As mentioned before, the above probiotics are the best on the market. As you noticed, there are tons of benefits with these supplements, but there are also some disadvantages, depending on the person’s body.

As with any supplement, it’s always best to consult your doctor before making a purchase. Other than that, the best option on the probiotic supplement above is the Hyperbiotics PRO-15 Probiotics.

These probiotic supplements have the least important disadvantages and far more benefits than others mentioned above. With these supplements, you will be safe with all natural ingredients. So, get them now while supplies last.


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